There was a significant relation between protein synthesis and fat-free mass ( r = 0.83, P <0.001) as well as between protein synthesis and REE ( r = 0.79, P < 0.005).Ĭonclusions: Obesity in prepubertal children is associated with an absolute increase in whole-body protein turnover that is consistent with an absolute increase in fat-free mass, both of which contribute to explaining the greater absolute REE in obese children than in control children.Įnergy metabolism, resting metabolic rate, protein metabolism, whole-body protein turnover, protein synthesis, fat-free mass, obesity, children INTRODUCTIONĪlthough much research has been conducted on human obesity in the past decades, more investigations have been performed of adult obesity than of childhood onset obesity. When these variables were adjusted for fat-free mass by analysis of covariance, however, the differences between groups disappeared. Results: Absolute rates of protein synthesis and breakdown were significantly greater in obese children than in control children ( x̄ ± SE: 208 ± 24 compared with 137 ± 14 g/d, P < 0.05, and 149 ± 20 compared with 89 ± 13 g/d, P < 0.05, respectively). Whole-body nitrogen flux, protein synthesis, and protein breakdown were calculated postprandially over 9 h from 15N abundance in urinary ammonia by using a single oral dose of glycine resting energy expenditure (REE) was assessed by indirect calorimetry (canopy) and body composition by multiple skinfold-thickness measurements. Objective: We evaluated the kinetics of protein metabolism in obese, prepubertal children in the static phase of obesity.ĭesign: In this cross-sectional study, 9 obese children ( x̄ ± SE: 44 ± 4 kg, 30.9 ± 1.5% body fat) were compared with 8 lean (28 ± 2 kg ,16.8 ± 1.2% body fat), age-matched (8.5 ± 0.2 y) control children. Background: Obesity is becoming more frequent in children understanding the extent to which this condition affects not only carbohydrate and lipid metabolism but also protein metabolism is of paramount importance.
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